Announcing a new article publication for Zoonoses journal. Arthritogenic alphaviruses, such as Ross River virus, chikungunya virus and O’nyong-nyong virus, cause endemic disease globally and are a major public health concern. The hallmarks of arthritogenic alphavirus disease are debilitating pain, and potentially chronic inflammation of the muscles, thus influencing quality of life. The type I IFN response is a major component of the innate immune response against arthritogenic alphaviruses and is essential in inhibiting viral replication and dissemination. Type I IFNs are induced during early stages of infection and are essential for the activation of the antiviral innate immune response. They also link the innate immune response and the activation of adaptive immunity.
The authors of this article review the host immune response, particularly that involving type I IFN, in arthritogenic alphavirus disease.
Article reference: Patrick Chun Hean Tang, Wern Hann Ng and Xiang Liu. Host Immune Responses to Arthritogenic Alphavirus Infection, with Emphasis on Type I IFN Responses. Zoonoses. Vol. 2(1). DOI: 10.15212/ZOONOSES-2022-0028
Keywords: alphavirus, innate immune response, Type I IFN, antagonism
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