Announcing a new article publication for Zoonoses journal. Brucellosis is a serious zoonotic infection worldwide. To date, vaccination is the most effective measure against brucellosis. This study was aimed at obtaining a vaccine strain that has high protective efficacy and low toxicity, and allows vaccination to be differentiated from infection.
Using homologous recombination, the authors constructed a double gene-deletion Brucella strain MB6 Δbp26ΔwboA (RM6) and evaluated its characteristics, safety and efficacy.
The RM6 strain had good proliferative ability and stable biological characteristics in vivo and in vitro. Moreover, it had a favorable safety profile and elicited specific immune responses in mice and sheep.
The RM6 strain may have substantial practical application value.
Article reference: Bochang Shi, Xinyu Li and Bo Li et al. Construction and Evaluation of the Brucella Double Gene Knock-out Vaccine Strain MB6 Δbp26ΔwboA (RM6). Zoonoses. Vol. 2(1). DOI: 10.15212/ZOONOSES-2022-0031
Keywords: brucellosis, Brucella 2 , vaccine3 , bp264 , wboA5 , homologous recombination6
Zoonoses is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases.
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