Announcing a new article publication for Zoonoses journal. Mycobacterium tuberculosis (Mtb) persister formation under antibiotic pressure is the main reason for long tuberculosis treatment and relapse. A key first-line antibiotic in TB treatment is pyrazinamide (PZA). The authors of this article established an in vitro assay, the time to detection (TTD) assay, to identify persister formation after PZA exposure, by using the BD BACTEC™ MGIT™ 960 system. After treatment of Mtb H37Rv with PZA even at 20 times the MIC, not all bacteria were killed, and persisters formed in the culture. These findings may explain the reasons for relapse after treatment. Moreover, the TTD assay developed herein may provide a valuable tool for research on persister formation under the pressure of various antibiotics.
Read More: https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2024-0025
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eISSN 2737-7474
ISSN 2737-7466
Shuqi Wang, Qing Sun and Guanglu Jiang et al. Mycobacterium Tuberculosis Persister Cell Formation after Pyrazinamide Exposure. Zoonoses. 2024. Vol. 4(1). DOI: 10.15212/ZOONOSES-2024-0025