Tag: Drug resistance

Metabolic Analysis of the Mode of Action and Mode of Resistance for Novobiocin in Staphylococcus aureus

Announcing a new article publication for Zoonoses journal. Methicillin resistant Staphylococcus aureus (MRSA) and Vancomycin resistant Staphylococcus aureus (VRSA) are critical pathogens identified by the WHO for their significant drug resistance. Targeting of bacterial gyrase, specifically the gyrB subunit, is a promising approach because of this enzyme’s essential role in bacterial DNA replication and its absence in higher eukaryotes. […]

Mycobacterium Tuberculosis Persister Cell Formation after Pyrazinamide Exposure

Mycobacterium Tuberculosis Persister Cell Formation after Pyrazinamide Exposure

Announcing a new article publication for Zoonoses journal.  Mycobacterium tuberculosis (Mtb) persister formation under antibiotic pressure is the main reason for long tuberculosis treatment and relapse. A key first-line antibiotic in TB treatment is pyrazinamide (PZA). The authors of this article established an in vitro assay, the time to detection (TTD) assay, to identify persister formation after PZA […]