Tag: obligate intracellular bacteria

Protective Immunity and Immunopathology in Ehrlichiosis

Announcing a new article publication for Zoonoses journal.  Human monocytic ehrlichiosis, a tick transmitted infection, ranges in severity from apparently subclinical to fatal toxic shock-like disease. Models in immunocompetent mice range from abortive to uniformly lethal infection, depending on the Ehrlichia species, inoculum dose, and inoculation route. Effective immunity is mediated by CD4+ T lymphocytes and gamma interferon. […]

Pattern Recognition Receptors in Innate Immunity to Obligate Intracellular Bacteria

Announcing a new article publication for Zoonoses journal. Researchers from University of Texas Medical Branch, Galveston, TX, USA review pattern recognition receptors in innate immunity to obligate intracellular bacteria. Host pattern recognition receptors (PRRs) are crucial for sensing pathogenic microorganisms, initiating innate responses, and modulating pathogen specific adaptive immunity during infection. Rickettsia spp., Orientia tsutsugamushi, […]