Tag: Bioinformatics

RNA-seq Analysis of the BCG Vaccine in a Humanized Mouse Model

Announcing a new article publication for Zoonoses journal.  This study was aimed at screening differentially expressed genes (DEGs) and exploring the potential immune mechanism induced by the Bacillus Calmette-Guerin (BCG) vaccine in a humanized mouse model.   Candidate DEGs between mice vaccinated with BCG or injected with PBS were identified through transcriptomics, and their biological […]

In silico Design of a Crimean-Congo Hemorrhagic Fever Virus Glycoprotein Multi-Epitope Antigen for Vaccine Development

Announcing a new article publication for Zoonoses journal.  No licensed vaccine is available to prevent the severe tick-borne disease Crimean-Congo hemorrhagic fever (CCHF), caused by the CCHF virus (CCHFV). This study sought to show that a combination of computational methods and data from published literature can inform the design of a multi-epitope antigen for CCHFV […]