Announcing a new article publication for Zoonoses journal. Evidence indicates that coxsackievirus B5 (CVB5) can cause meningitis, and hand, foot, and mouth disease (HFMD), and is associated with type 1 diabetes. No effective drug or vaccine is available for treating CVB5 infections or controlling outbreaks.
The Vero-cell-adapted vaccine candidate strain KM299-L05 underwent comprehensive phylogenetic analysis, sequence alignment, assessment of virulence in BALB/c mice, Vero cell acclimation, three successive rounds of plaque purification, preparation of experimental vaccines, and immunogenicity evaluation.
KM299-L05 was the most virulent strain in BALB/c mice. Its infectious titer reached 108.0 CCID50/mL in Vero cells, and it belonged to the Chinese epidemic genotype C3. An inactivated CVB5 vaccine derived from the KM299-L05 strain produced neutralizing antibodies with a titer range from 1:384 to 1:768 against a variety of clinical CVB5 isolates, particularly the prototype strain. Maternal antibodies fully protected all examined suckling BALB/c mice against lethal challenge.
Although the study was limited to neonatal mice, our findings suggested that the KM299-L05 strain has potential as a novel CVB5 vaccine candidate in China, and provide a rationale for the development of a CVB5 vaccine.
VEEV was detected annually in 23.4% (128/548) of the cases, while EEEV appeared intermittently (1.5% [8/548]).
Read full article: https://www.scienceopen.com/hosted-document?doi=10.15212/ZOONOSES-2025-0004
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eISSN 2737-7474
ISSN 2737-7466
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Yuhan Liu, Zhaoyang Chu and Ming Zhang et al. A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties. Zoonoses. 2025. Vol. 5(1). DOI: 10.15212/ZOONOSES-2025-0004