{"id":861,"date":"2023-02-13T17:23:08","date_gmt":"2023-02-13T17:23:08","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=861"},"modified":"2023-02-13T17:23:08","modified_gmt":"2023-02-13T17:23:08","slug":"preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/","title":{"rendered":"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect"},"content":{"rendered":"<p>Announcing a new article publication for <em>Zoonoses<\/em> journal. \u00a0Smallpox, a severe infectious disease caused by the smallpox virus, causes a death rate as high as 30% within 15-20 days after infection. Therefore, development of anti-Smallpox product as a strategic reserve is urgently needed.<\/p>\n<p>Pepsin-digested F(ab\u2032)<sub>2<\/sub>\u00a0fragments of serum IgG from horses was prepared and tested. Transmission electron microscopy indicated that the purified virus showed morphology consistent with VVTT. The titer was above 1.0 \u00d7 10<sup>7<\/sup>\u00a0PFU\/mL. The purity of the antigen exceeded 90%, according to HPLC. After purification and cleavage, the yield of the purified product F(ab\u2032)<sub>2<\/sub>\u00a0was approximately 1.3%, its purity exceeded 90%, and the neutralizing antibody titer exceeded 1:3200. F(ab\u2032)<sub>2<\/sub>\u00a0fragments had good preventive and therapeutic effects in mice at antibody doses of 5.2 mg\/mL and 2.6 mg\/mL. The viral loads of the drug-treated mice were suppressed to varying degrees, and the higher dose groups (5.2 and 2.6 mg\/mL) showed a 2-3 fold lower viral load than that in the control group.<\/p>\n<p>A process for producing equine immunoglobulin F(ab\u2032)<sub>2<\/sub>\u00a0against VVTT was established. The prepared horse anti-smallpox immunoglobulin product had good neutralizing antibody effects on VVTT. The highly purified preparation may serve as a potential candidate for smallpox treatment.<\/p>\n<p><em>Zoonoses<\/em> is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases.<\/p>\n<p><em>Zoonoses<\/em> is now open for submissions; articles can be submitted online at <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a><\/p>\n<p>Please visit <a href=\"https:\/\/zoonoses-journal.org\/%20\">https:\/\/zoonoses-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/\">https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p><strong><em>Zoonoses<\/em><\/strong> is available on <a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">ScienceOpen<\/a> (<a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700<\/a>).<\/p>\n<p>Submissions may be made using <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">ScholarOne<\/a> (<a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a>).<\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Zoonoses <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/ZoonosesJ\">@ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114<\/a> ) and <a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">LinkedIn<\/a> (<a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">https:\/\/www.linkedin.com\/company\/zoonoses\/<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7474<\/p>\n<p><strong>ISSN<\/strong> 2737-7466<\/p>\n<p><strong>Article reference: <\/strong>Bochang Shi, Hui Han and Lingyun Tan et al. Preparation of Equine Immunoglobulin F(ab\u2032)2 against Smallpox and Evaluation of its Immunoprotective Effect.\u00a0<em>Zoonoses.\u00a0<\/em>Vol. 3(1). DOI: 10.15212\/ZOONOSES-2022-0048<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new article publication for Zoonoses journal. \u00a0Smallpox, a severe infectious disease caused by the smallpox virus, causes a death rate as high as 30% within 15-20 days after infection. Therefore, development of anti-Smallpox product as a strategic reserve is urgently needed. Pepsin-digested F(ab\u2032)2\u00a0fragments of serum IgG from horses was prepared and tested. Transmission [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-861","post","type-post","status-publish","format-standard","hentry","category-news-and-events"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect - Zoonoses Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect - Zoonoses Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new article publication for Zoonoses journal. \u00a0Smallpox, a severe infectious disease caused by the smallpox virus, causes a death rate as high as 30% within 15-20 days after infection. Therefore, development of anti-Smallpox product as a strategic reserve is urgently needed. Pepsin-digested F(ab\u2032)2\u00a0fragments of serum IgG from horses was prepared and tested. Transmission [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/\" \/>\n<meta property=\"og:site_name\" content=\"Zoonoses Journal\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\" \/>\n<meta property=\"article:published_time\" content=\"2023-02-13T17:23:08+00:00\" \/>\n<meta name=\"author\" content=\"TerNo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:site\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"TerNo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/13\\\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/13\\\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\\\/\"},\"author\":{\"name\":\"TerNo\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/person\\\/9a2c3e8a3ddb9f181597a77f5090d067\"},\"headline\":\"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect\",\"datePublished\":\"2023-02-13T17:23:08+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/13\\\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\\\/\"},\"wordCount\":358,\"publisher\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\"},\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/13\\\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\\\/\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/13\\\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\\\/\",\"name\":\"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect - Zoonoses Journal\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#website\"},\"datePublished\":\"2023-02-13T17:23:08+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/13\\\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/13\\\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/13\\\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/zoonoses-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/\",\"name\":\"Zoonoses Journal\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/zoonoses-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\",\"name\":\"Zoonoses Journal\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/cropped-cropped-Zoonoses_logo_small-1.png\",\"contentUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/cropped-cropped-Zoonoses_logo_small-1.png\",\"width\":512,\"height\":512,\"caption\":\"Zoonoses Journal\"},\"image\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/Zoonoses-Journal-100462755574114\",\"https:\\\/\\\/x.com\\\/ZoonosesJ\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/78022634\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/person\\\/9a2c3e8a3ddb9f181597a77f5090d067\",\"name\":\"TerNo\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/litespeed\\\/avatar\\\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1776182108\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/litespeed\\\/avatar\\\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1776182108\",\"contentUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/litespeed\\\/avatar\\\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1776182108\",\"caption\":\"TerNo\"},\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/author\\\/terno\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect - Zoonoses Journal","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/","og_locale":"en_US","og_type":"article","og_title":"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect - Zoonoses Journal","og_description":"Announcing a new article publication for Zoonoses journal. \u00a0Smallpox, a severe infectious disease caused by the smallpox virus, causes a death rate as high as 30% within 15-20 days after infection. Therefore, development of anti-Smallpox product as a strategic reserve is urgently needed. Pepsin-digested F(ab\u2032)2\u00a0fragments of serum IgG from horses was prepared and tested. Transmission [&hellip;]","og_url":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/","og_site_name":"Zoonoses Journal","article_publisher":"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114","article_published_time":"2023-02-13T17:23:08+00:00","author":"TerNo","twitter_card":"summary_large_image","twitter_creator":"@ZoonosesJ","twitter_site":"@ZoonosesJ","twitter_misc":{"Written by":"TerNo","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/#article","isPartOf":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/"},"author":{"name":"TerNo","@id":"https:\/\/zoonoses-journal.org\/#\/schema\/person\/9a2c3e8a3ddb9f181597a77f5090d067"},"headline":"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect","datePublished":"2023-02-13T17:23:08+00:00","mainEntityOfPage":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/"},"wordCount":358,"publisher":{"@id":"https:\/\/zoonoses-journal.org\/#organization"},"articleSection":["News and Events"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/","url":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/","name":"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect - Zoonoses Journal","isPartOf":{"@id":"https:\/\/zoonoses-journal.org\/#website"},"datePublished":"2023-02-13T17:23:08+00:00","breadcrumb":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/13\/preparation-of-equine-immunoglobulin-against-smallpox-and-evaluation-of-its-immunoprotective-effect\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/zoonoses-journal.org\/"},{"@type":"ListItem","position":2,"name":"Preparation of Equine Immunoglobulin against Smallpox and Evaluation of its Immunoprotective Effect"}]},{"@type":"WebSite","@id":"https:\/\/zoonoses-journal.org\/#website","url":"https:\/\/zoonoses-journal.org\/","name":"Zoonoses Journal","description":"","publisher":{"@id":"https:\/\/zoonoses-journal.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/zoonoses-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/zoonoses-journal.org\/#organization","name":"Zoonoses Journal","url":"https:\/\/zoonoses-journal.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/zoonoses-journal.org\/#\/schema\/logo\/image\/","url":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2021\/03\/cropped-cropped-Zoonoses_logo_small-1.png","contentUrl":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2021\/03\/cropped-cropped-Zoonoses_logo_small-1.png","width":512,"height":512,"caption":"Zoonoses Journal"},"image":{"@id":"https:\/\/zoonoses-journal.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114","https:\/\/x.com\/ZoonosesJ","https:\/\/www.linkedin.com\/company\/78022634"]},{"@type":"Person","@id":"https:\/\/zoonoses-journal.org\/#\/schema\/person\/9a2c3e8a3ddb9f181597a77f5090d067","name":"TerNo","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/zoonoses-journal.org\/wp-content\/litespeed\/avatar\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1776182108","url":"https:\/\/zoonoses-journal.org\/wp-content\/litespeed\/avatar\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1776182108","contentUrl":"https:\/\/zoonoses-journal.org\/wp-content\/litespeed\/avatar\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1776182108","caption":"TerNo"},"url":"https:\/\/zoonoses-journal.org\/index.php\/author\/terno\/"}]}},"_links":{"self":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/861","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=861"}],"version-history":[{"count":1,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/861\/revisions"}],"predecessor-version":[{"id":862,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/861\/revisions\/862"}],"wp:attachment":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=861"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=861"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=861"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}