{"id":848,"date":"2023-02-02T15:20:32","date_gmt":"2023-02-02T15:20:32","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=848"},"modified":"2023-02-02T15:20:32","modified_gmt":"2023-02-02T15:20:32","slug":"identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/","title":{"rendered":"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum"},"content":{"rendered":"<h5>Announcing a new article publication for <em>Zoonoses<\/em> journal. As infections caused by nontuberculous mycobacteria (NTM) are rapidly increasing globally, a need exists for developing novel antibiotics and discovering the mechanism of resistance. This research reported by this article was aimed at understanding the mechanism of bedaquiline resistance in the model NTM species\u00a0<em>Mycobacterium marinum<\/em>\u00a0(<em>M. marinum<\/em>).<\/h5>\n<p>The\u00a0<em>Mycobacterium marinum<\/em>\u00a0M strain was subjected to mutant selection with different concentrations of BDQ. After three rounds of evolution, 58 BDQ-resistant mutants were isolated and subjected to WGS. The results were confirmed through PCR and Sanger sequencing.<\/p>\n<p>Seven genetic mutations among these mutants were identified. The highest drug resistance (6\u201310\u00d7 MIC) was associated with a mutation in AtpB, the primary biochemical target of BDQ in Mtb. Numerous mutations and insertions mapped to the gene\u00a0<em>MMAR_1007<\/em>(46\/58), which encodes the homolog of Rv0678 (MmpR) in Mtb. More than 93% of mutants (54\/58) contained a single mutation (G563A) in\u00a0<em>MMAR_4049<\/em>, which encodes the integral membrane protein YrbE3A-1.<\/p>\n<p>Both target-based and efflux-based actions contribute to BDQ resistance in\u00a0<em>M. marinum.<\/em>\u00a0These findings may aid in developing novel potent anti-NTM (BDQ-based) drug regimens and diagnostic assays for the detection of BDQ-resistant\u00a0<em>M. marinum<\/em>.<\/p>\n<p><a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2022-0042\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2022-0042<\/a><\/p>\n<p><em>Zoonoses<\/em> is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases.<\/p>\n<p><em>Zoonoses<\/em> is now open for submissions; articles can be submitted online at <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a><\/p>\n<p>Please visit <a href=\"https:\/\/zoonoses-journal.org\/%20\">https:\/\/zoonoses-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/\">https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p><strong><em>Zoonoses<\/em><\/strong> is available on <a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">ScienceOpen<\/a> (<a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700<\/a>).<\/p>\n<p>Submissions may be made using <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">ScholarOne<\/a> (<a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a>).<\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Zoonoses <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/ZoonosesJ\">@ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114<\/a> ) and <a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">LinkedIn<\/a> (<a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">https:\/\/www.linkedin.com\/company\/zoonoses\/<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7474<\/p>\n<p><strong>ISSN<\/strong> 2737-7466<\/p>\n<p><strong>Article reference: <\/strong>Longlong Wang, Yufan Xu and Zhe Wang. Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum.\u00a0<em>Zoonoses.\u00a0<\/em>Vol. 3(1). DOI: 10.15212\/ZOONOSES-2022-0042<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new article publication for Zoonoses journal. As infections caused by nontuberculous mycobacteria (NTM) are rapidly increasing globally, a need exists for developing novel antibiotics and discovering the mechanism of resistance. This research reported by this article was aimed at understanding the mechanism of bedaquiline resistance in the model NTM species\u00a0Mycobacterium marinum\u00a0(M. marinum). The\u00a0Mycobacterium [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[],"class_list":["post-848","post","type-post","status-publish","format-standard","hentry","category-news-and-events"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.6 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum - Zoonoses Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum - Zoonoses Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new article publication for Zoonoses journal. As infections caused by nontuberculous mycobacteria (NTM) are rapidly increasing globally, a need exists for developing novel antibiotics and discovering the mechanism of resistance. This research reported by this article was aimed at understanding the mechanism of bedaquiline resistance in the model NTM species\u00a0Mycobacterium marinum\u00a0(M. marinum). The\u00a0Mycobacterium [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/\" \/>\n<meta property=\"og:site_name\" content=\"Zoonoses Journal\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\" \/>\n<meta property=\"article:published_time\" content=\"2023-02-02T15:20:32+00:00\" \/>\n<meta name=\"author\" content=\"TerNo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:site\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"TerNo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/02\\\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/02\\\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\\\/\"},\"author\":{\"name\":\"TerNo\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/person\\\/9a2c3e8a3ddb9f181597a77f5090d067\"},\"headline\":\"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum\",\"datePublished\":\"2023-02-02T15:20:32+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/02\\\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\\\/\"},\"wordCount\":356,\"publisher\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\"},\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/02\\\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\\\/\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/02\\\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\\\/\",\"name\":\"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum - Zoonoses Journal\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#website\"},\"datePublished\":\"2023-02-02T15:20:32+00:00\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/02\\\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/02\\\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\\\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/02\\\/02\\\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/zoonoses-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/\",\"name\":\"Zoonoses Journal\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/zoonoses-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\",\"name\":\"Zoonoses Journal\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/cropped-cropped-Zoonoses_logo_small-1.png\",\"contentUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/cropped-cropped-Zoonoses_logo_small-1.png\",\"width\":512,\"height\":512,\"caption\":\"Zoonoses Journal\"},\"image\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/Zoonoses-Journal-100462755574114\",\"https:\\\/\\\/x.com\\\/ZoonosesJ\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/78022634\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/person\\\/9a2c3e8a3ddb9f181597a77f5090d067\",\"name\":\"TerNo\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/litespeed\\\/avatar\\\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1778603031\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/litespeed\\\/avatar\\\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1778603031\",\"contentUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/litespeed\\\/avatar\\\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1778603031\",\"caption\":\"TerNo\"},\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/author\\\/terno\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum - Zoonoses Journal","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/","og_locale":"en_US","og_type":"article","og_title":"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum - Zoonoses Journal","og_description":"Announcing a new article publication for Zoonoses journal. As infections caused by nontuberculous mycobacteria (NTM) are rapidly increasing globally, a need exists for developing novel antibiotics and discovering the mechanism of resistance. This research reported by this article was aimed at understanding the mechanism of bedaquiline resistance in the model NTM species\u00a0Mycobacterium marinum\u00a0(M. marinum). The\u00a0Mycobacterium [&hellip;]","og_url":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/","og_site_name":"Zoonoses Journal","article_publisher":"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114","article_published_time":"2023-02-02T15:20:32+00:00","author":"TerNo","twitter_card":"summary_large_image","twitter_creator":"@ZoonosesJ","twitter_site":"@ZoonosesJ","twitter_misc":{"Written by":"TerNo","Est. reading time":"2 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/#article","isPartOf":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/"},"author":{"name":"TerNo","@id":"https:\/\/zoonoses-journal.org\/#\/schema\/person\/9a2c3e8a3ddb9f181597a77f5090d067"},"headline":"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum","datePublished":"2023-02-02T15:20:32+00:00","mainEntityOfPage":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/"},"wordCount":356,"publisher":{"@id":"https:\/\/zoonoses-journal.org\/#organization"},"articleSection":["News and Events"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/","url":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/","name":"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum - Zoonoses Journal","isPartOf":{"@id":"https:\/\/zoonoses-journal.org\/#website"},"datePublished":"2023-02-02T15:20:32+00:00","breadcrumb":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/"]}]},{"@type":"BreadcrumbList","@id":"https:\/\/zoonoses-journal.org\/index.php\/2023\/02\/02\/identification-of-novel-mutations-associated-with-bedaquiline-resistance-in-mycobacterium-marinum\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/zoonoses-journal.org\/"},{"@type":"ListItem","position":2,"name":"Identification of Novel Mutations Associated with Bedaquiline Resistance in Mycobacterium Marinum"}]},{"@type":"WebSite","@id":"https:\/\/zoonoses-journal.org\/#website","url":"https:\/\/zoonoses-journal.org\/","name":"Zoonoses Journal","description":"","publisher":{"@id":"https:\/\/zoonoses-journal.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/zoonoses-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/zoonoses-journal.org\/#organization","name":"Zoonoses Journal","url":"https:\/\/zoonoses-journal.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/zoonoses-journal.org\/#\/schema\/logo\/image\/","url":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2021\/03\/cropped-cropped-Zoonoses_logo_small-1.png","contentUrl":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2021\/03\/cropped-cropped-Zoonoses_logo_small-1.png","width":512,"height":512,"caption":"Zoonoses Journal"},"image":{"@id":"https:\/\/zoonoses-journal.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114","https:\/\/x.com\/ZoonosesJ","https:\/\/www.linkedin.com\/company\/78022634"]},{"@type":"Person","@id":"https:\/\/zoonoses-journal.org\/#\/schema\/person\/9a2c3e8a3ddb9f181597a77f5090d067","name":"TerNo","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/zoonoses-journal.org\/wp-content\/litespeed\/avatar\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1778603031","url":"https:\/\/zoonoses-journal.org\/wp-content\/litespeed\/avatar\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1778603031","contentUrl":"https:\/\/zoonoses-journal.org\/wp-content\/litespeed\/avatar\/e843b0ec2efa3c370cad2034a56e668f.jpg?ver=1778603031","caption":"TerNo"},"url":"https:\/\/zoonoses-journal.org\/index.php\/author\/terno\/"}]}},"_links":{"self":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/848","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/users\/8"}],"replies":[{"embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=848"}],"version-history":[{"count":1,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/848\/revisions"}],"predecessor-version":[{"id":849,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/848\/revisions\/849"}],"wp:attachment":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=848"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=848"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=848"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}