{"id":835,"date":"2023-01-24T12:49:07","date_gmt":"2023-01-24T12:49:07","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=835"},"modified":"2023-01-24T12:51:54","modified_gmt":"2023-01-24T12:51:54","slug":"prnp-sequences-of-tibetan-antelope-blue-sheep-and-plateau-pika-from-the-qinghai-tibet-plateau-and-reactivity-of-prp-proteins-to-rodent-adapted-scrapie-strains-in-rt-quic-and-pmca","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2023\/01\/24\/prnp-sequences-of-tibetan-antelope-blue-sheep-and-plateau-pika-from-the-qinghai-tibet-plateau-and-reactivity-of-prp-proteins-to-rodent-adapted-scrapie-strains-in-rt-quic-and-pmca\/","title":{"rendered":"PRNP Sequences of Tibetan Antelope, Blue Sheep, and Plateau Pika from the Qinghai-Tibet Plateau and Reactivity of PrP Proteins to Rodent-Adapted Scrapie Strains in RT-QuIC and PMCA"},"content":{"rendered":"
Announcing a new article publication for Zoonoses<\/em> journal. \u00a0\u00a0<\/em>Tibetan antelope (Rhinopithecus<\/em>), blue sheep (Pseudois nayauris<\/em>), and plateau pika (Ochotona curzoniae<\/em>) are wild animals living on the Qinghai-Tibet Plateau. There have been no reports of naturally-occurring transmissible spongioform encephalopathies (TSEs) involving these animals. Furthermore, the\u00a0PRNP<\/em>\u00a0genes have not been described in the literature.<\/h5>\n

The\u00a0PRNP<\/em>\u00a0genes from 21 Tibetan antelopes, 4 blue sheep, and 3 plateau pikas were obtained and sequenced. The recombinant proteins were then prepared. Using scrapie strains (263K, 139A, ME7, and S15) as the seeds, the reactivity of the PrP proteins from sheep (rSheepPrP25-234) and pika (rPikaPrP23-230) were tested using real-time quaking-induced conversion (RT-QuIC). Protein misfolding cyclic amplification (PMCA) tests of the brain homogenates from domestic sheep and rabbits were performed with the seeds of strains 263K and ME7.<\/p>\n

The\u00a0PRNP<\/em>\u00a0genes of bovids were 771 bp long and encoded 256 amino acids (aa), showing 100% homology with the wild-type sheep prion protein (PrP) aa sequence. The\u00a0PRNP<\/em>\u00a0gene of pika was 759 bp long and encoded 252 amino acids, showing 92.1% homology with the aa sequence of domestic rabbits. The sheep and pika proteins revealed positive reactions in 10-5<\/sup>\u00a0diluted seeds. Only rPikaPrP23-230 produced positive curves in 10-7<\/sup>\u00a0diluted seeds. The PMCA tests failed to produce proteinase K (PK)-resistant PrP (PrPres<\/sup>).<\/p>\n

This is the first description of\u00a0PRNP<\/em>\u00a0genes and PrP aa sequences of Tibetan antelope, blue sheep, and plateau pike from the Qinghai-Tibet Plateau. In the presence of rodent prions, the PrPs of sheep and pika efficiently induce fibrillation in RT-QuIC, but do not generate PrPres<\/sup>\u00a0in PMCA. Our results indicate that pika, as one of the important links in the Qinghai-Tibet Plateau biological chain, may play an important role in the prion circulation. Pika PrP deserves further analysis for its potential application value in assays for human prion disease.<\/p>\n

https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2022-0036<\/a><\/p>\n

Keywords:<\/strong> Tibetan antelope, blue sheep, plateau pika, PRNP<\/em>, RT-QuIC, PMCA<\/h5>\n

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ISSN<\/strong> 2737-7466<\/p>\n

Article reference: <\/strong>Yue-Zhang Wu, Jing-Xing Wu and Xue-Hua Yang et al. PRNP Sequences of Tibetan Antelope, Blue Sheep, and Plateau Pika from the Qinghai-Tibet Plateau and Reactivity of PrP Proteins to Rodent-Adapted Scrapie Strains in RT-QuIC and PMCA.\u00a0Zoonoses.\u00a0<\/em>Vol. 3(1). DOI: 10.15212\/ZOONOSES-2022-0036<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new article publication for Zoonoses journal. \u00a0\u00a0Tibetan antelope (Rhinopithecus), blue sheep (Pseudois nayauris), and plateau pika (Ochotona curzoniae) are wild animals living on the Qinghai-Tibet Plateau. There have been no reports of naturally-occurring transmissible spongioform encephalopathies (TSEs) involving these animals. Furthermore, the\u00a0PRNP\u00a0genes have not been described in the literature. The\u00a0PRNP\u00a0genes from 21 Tibetan […]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[233,234,237,235,236,232],"class_list":["post-835","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-blue-sheep","tag-plateau-pika","tag-pmca","tag-prnp","tag-rt-quic","tag-tibetan-antelope"],"yoast_head":"\nPRNP Sequences of Tibetan Antelope, Blue Sheep, and Plateau Pika from the Qinghai-Tibet Plateau and Reactivity of PrP Proteins to Rodent-Adapted Scrapie Strains in RT-QuIC and PMCA - Zoonoses Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zoonoses-journal.org\/index.php\/2023\/01\/24\/prnp-sequences-of-tibetan-antelope-blue-sheep-and-plateau-pika-from-the-qinghai-tibet-plateau-and-reactivity-of-prp-proteins-to-rodent-adapted-scrapie-strains-in-rt-quic-and-pmca\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"PRNP Sequences of Tibetan Antelope, Blue Sheep, and Plateau Pika from the Qinghai-Tibet Plateau and Reactivity of PrP Proteins to Rodent-Adapted Scrapie Strains in RT-QuIC and PMCA - Zoonoses Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new article publication for Zoonoses journal. \u00a0\u00a0Tibetan antelope (Rhinopithecus), blue sheep (Pseudois nayauris), and plateau pika (Ochotona curzoniae) are wild animals living on the Qinghai-Tibet Plateau. There have been no reports of naturally-occurring transmissible spongioform encephalopathies (TSEs) involving these animals. Furthermore, the\u00a0PRNP\u00a0genes have not been described in the literature. 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