{"id":707,"date":"2022-07-06T14:14:25","date_gmt":"2022-07-06T14:14:25","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=707"},"modified":"2022-07-06T14:14:25","modified_gmt":"2022-07-06T14:14:25","slug":"protective-immunity-and-immunopathology-in-ehrlichiosis","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2022\/07\/06\/protective-immunity-and-immunopathology-in-ehrlichiosis\/","title":{"rendered":"Protective Immunity and Immunopathology in Ehrlichiosis"},"content":{"rendered":"<p>Announcing a new article publication for <em>Zoonoses<\/em> journal. \u00a0Human monocytic ehrlichiosis, a tick transmitted infection, ranges in severity from apparently subclinical to fatal toxic shock-like disease.<\/p>\n<p>Models in immunocompetent mice range from abortive to uniformly lethal infection, depending on the\u00a0<em>Ehrlichia<\/em>\u00a0species, inoculum dose, and inoculation route. Effective immunity is mediated by CD4<sup>+<\/sup>\u00a0T lymphocytes and gamma interferon. Lethal infection occurs with early overproduction of proinflammatory cytokines and overproduction of TNF alpha and IL-10 by CD8<sup>+<\/sup>\u00a0T lymphocytes. Furthermore, fatal ehrlichiosis is associated with TLR 9\/MyD88 signaling, upregulation of several inflammasome complexes, and secretion of IL-1 beta, IL-1 alpha, and IL-18 by hepatic mononuclear cells, thus suggesting activation of canonical and noncanonical inflammasome pathways, a deleterious role of IL-18, and a protective role of caspase 1. Autophagy promotes ehrlichial infection, whereas MyD88 signaling hinders ehrlichial infection by inhibiting autophagy induction and flux. During infection of hepatocytes by the lethal ehrlichial species, after interferon alpha receptor signaling, the activation of caspase 11 results in the production of inflammasome-dependent IL-1 beta, extracellular secretion of HMGB1, and pyroptosis. HMGB1 has high levels in lethal ehrlichiosis, thereby suggesting a role in toxic shock.<\/p>\n<p>Studies of primary bone marrow-derived macrophages infected by highly avirulent or mildly avirulent ehrlichiae have revealed divergent M1 and M2 macrophage polarization associated with the generation of pathogenic CD8 T cells and neutrophils, and excessive inflammation, or with strong expansion of protective Th1 and NKT cells, resolution of inflammation, and clearance of infection, respectively.<\/p>\n<p><strong>Article reference:<\/strong> Nahed Ismail, Aditya Sharma and Lynn Soong et al. Protective Immunity and Immunopathology in Ehrlichiosis.\u00a0<em>Zoonoses.\u00a0<\/em>Vol. 2(1). DOI: 10.15212\/ZOONOSES-2022-0009<\/p>\n<p><strong>Keywords:<\/strong> Ehrlichiosis, Ehrlichia, obligate intracellular bacteria, immunity, inflammasomes, autophagy, type I interferon, pattern recognition receptors, macrophage polarization<\/p>\n<p><em>Zoonoses<\/em> is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases.<\/p>\n<p><em>Zoonoses<\/em> is now open for submissions; articles can be submitted online at <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a><\/p>\n<p>Please visit <a href=\"https:\/\/zoonoses-journal.org\/\">https:\/\/zoonoses-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/\">https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p><strong><em>Zoonoses<\/em><\/strong> is available on <a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">ScienceOpen<\/a> (<a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700<\/a>).<\/p>\n<p>&nbsp;<\/p>\n<p>Submissions may be made using <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">ScholarOne<\/a> (<a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a>).<\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>&nbsp;<\/p>\n<p>Follow <strong><em>Zoonoses <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/ZoonosesJ\">@ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114<\/a> ) and <a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">LinkedIn<\/a> (<a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">https:\/\/www.linkedin.com\/company\/zoonoses\/<\/a>)<\/p>\n<p><strong>\u00a0<\/strong><\/p>\n<p><strong>eISSN <\/strong>2737-7474<\/p>\n<p><strong>ISSN<\/strong> 2737-7466<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new article publication for Zoonoses journal. \u00a0Human monocytic ehrlichiosis, a tick transmitted infection, ranges in severity from apparently subclinical to fatal toxic shock-like disease. Models in immunocompetent mice range from abortive to uniformly lethal infection, depending on the\u00a0Ehrlichia\u00a0species, inoculum dose, and inoculation route. Effective immunity is mediated by CD4+\u00a0T lymphocytes and gamma interferon. [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[149,64,146,147,148,152,60,151,150],"class_list":["post-707","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-autophagy","tag-ehrlichia","tag-ehrlichiosis","tag-immunity","tag-inflammasomes","tag-macrophage-polarization","tag-obligate-intracellular-bacteria","tag-pattern-recognition-receptors","tag-type-i-interferon"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Protective Immunity and Immunopathology in Ehrlichiosis - Zoonoses Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zoonoses-journal.org\/index.php\/2022\/07\/06\/protective-immunity-and-immunopathology-in-ehrlichiosis\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Protective Immunity and Immunopathology in Ehrlichiosis - Zoonoses Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new article publication for Zoonoses journal. \u00a0Human monocytic ehrlichiosis, a tick transmitted infection, ranges in severity from apparently subclinical to fatal toxic shock-like disease. Models in immunocompetent mice range from abortive to uniformly lethal infection, depending on the\u00a0Ehrlichia\u00a0species, inoculum dose, and inoculation route. Effective immunity is mediated by CD4+\u00a0T lymphocytes and gamma interferon. 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