{"id":636,"date":"2022-01-12T12:07:57","date_gmt":"2022-01-12T12:07:57","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=636"},"modified":"2022-01-28T15:26:40","modified_gmt":"2022-01-28T15:26:40","slug":"venezuelan-equine-encephalitis-virus-v3526-vaccine-rna-dependent-rna-polymerase-mutants-increase-vaccine-safety-through-restricted-tissue-tropism-in-a-mouse-model","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2022\/01\/12\/venezuelan-equine-encephalitis-virus-v3526-vaccine-rna-dependent-rna-polymerase-mutants-increase-vaccine-safety-through-restricted-tissue-tropism-in-a-mouse-model\/","title":{"rendered":"Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Mouse Model"},"content":{"rendered":"<p>Announcing a new article publication for<em> Zoonoses<\/em> journal. Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas, for which no vaccines or antiviral agents have been approved. TC-83 and V3526 are the best-characterized vaccine candidates for VEEV. Both are live-attenuated vaccines and have been associated with safety concerns, although fewer concerns exist for V3526. A previous attempt to improve the TC-83 vaccine focused on further attenuating the vaccine by adding mutations that alter the error-incorporation rate of the RNA-dependent RNA polymerase (RdRp).<\/p>\n<p>The research in this article examined the effects of these RdRp mutations in V3526 by cloning the 3X and 4X strains, assessing vaccine efficacy against challenge in adult female CD-1 mice, examining neutralizing-antibody titers, investigating vaccine tissue tropism, and testing the stability of the mutant strains. The V3526 RdRp mutants exhibited less tissue tropism in the spleen and kidney than the wild-type V3526, while maintaining vaccine efficacy. Illumina sequencing indicated that the RdRp mutations reverted to wild-type V3526 after five passages in murine pup brains.<\/p>\n<p>The observed genotypic reversion is likely to be of limited concern, because wild-type V3526 remains an effective vaccine capable of providing protection. The results indicate that the V3526 RdRp mutants may be a safer vaccine design than the original V3526.<\/p>\n<p><strong>Article reference:<\/strong> Clint A. Haines, Rafael K. Campos and Sasha R. Azar et al. Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Mouse Model.\u00a0<em>Zoonoses.\u00a0<\/em>Vol. 2(1). DOI: 10.15212\/ZOONOSES-2021-0016<\/p>\n<p><strong>Keywords:<\/strong> Venezuelan equine encephalitis virus, TC-83, V3526, vaccine, fidelity<\/p>\n<p><em>Zoonoses<\/em> is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases.<\/p>\n<p><em>Zoonoses<\/em> is now open for submissions; articles can be submitted online at <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a><\/p>\n<p>Please visit <a href=\"https:\/\/zoonoses-journal.org\/%20\">https:\/\/zoonoses-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/\">https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p><strong><em>Zoonoses<\/em><\/strong> is available on <a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">ScienceOpen<\/a> (<a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700<\/a>).<\/p>\n<p>Submissions may be made using <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">ScholarOne<\/a> (<a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a>).<\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Zoonoses <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/ZoonosesJ\">@ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114<\/a> ) and <a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">LinkedIn<\/a> (<a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">https:\/\/www.linkedin.com\/company\/zoonoses\/<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7474<\/p>\n<p><strong>ISSN<\/strong> 2737-7466<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new article publication for Zoonoses journal. Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas, for which no vaccines or antiviral agents have been approved. TC-83 and V3526 are the best-characterized vaccine candidates for VEEV. Both are live-attenuated vaccines and have been associated with safety concerns, although fewer concerns exist [&hellip;]<\/p>\n","protected":false},"author":8,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[98,96,97,56,95],"class_list":["post-636","post","type-post","status-publish","format-standard","hentry","category-news-and-events","tag-fidelity","tag-tc-83","tag-v3526","tag-vaccine","tag-venezuelan-equine-encephalitis-virus"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Mouse Model - Zoonoses Journal<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zoonoses-journal.org\/index.php\/2022\/01\/12\/venezuelan-equine-encephalitis-virus-v3526-vaccine-rna-dependent-rna-polymerase-mutants-increase-vaccine-safety-through-restricted-tissue-tropism-in-a-mouse-model\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Mouse Model - Zoonoses Journal\" \/>\n<meta property=\"og:description\" content=\"Announcing a new article publication for Zoonoses journal. Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas, for which no vaccines or antiviral agents have been approved. TC-83 and V3526 are the best-characterized vaccine candidates for VEEV. Both are live-attenuated vaccines and have been associated with safety concerns, although fewer concerns exist [&hellip;]\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zoonoses-journal.org\/index.php\/2022\/01\/12\/venezuelan-equine-encephalitis-virus-v3526-vaccine-rna-dependent-rna-polymerase-mutants-increase-vaccine-safety-through-restricted-tissue-tropism-in-a-mouse-model\/\" \/>\n<meta property=\"og:site_name\" content=\"Zoonoses Journal\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\" \/>\n<meta property=\"article:published_time\" content=\"2022-01-12T12:07:57+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2022-01-28T15:26:40+00:00\" \/>\n<meta name=\"author\" content=\"TerNo\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:site\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"TerNo\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2022\\\/01\\\/12\\\/venezuelan-equine-encephalitis-virus-v3526-vaccine-rna-dependent-rna-polymerase-mutants-increase-vaccine-safety-through-restricted-tissue-tropism-in-a-mouse-model\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2022\\\/01\\\/12\\\/venezuelan-equine-encephalitis-virus-v3526-vaccine-rna-dependent-rna-polymerase-mutants-increase-vaccine-safety-through-restricted-tissue-tropism-in-a-mouse-model\\\/\"},\"author\":{\"name\":\"TerNo\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/person\\\/9a2c3e8a3ddb9f181597a77f5090d067\"},\"headline\":\"Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Mouse Model\",\"datePublished\":\"2022-01-12T12:07:57+00:00\",\"dateModified\":\"2022-01-28T15:26:40+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2022\\\/01\\\/12\\\/venezuelan-equine-encephalitis-virus-v3526-vaccine-rna-dependent-rna-polymerase-mutants-increase-vaccine-safety-through-restricted-tissue-tropism-in-a-mouse-model\\\/\"},\"wordCount\":399,\"publisher\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\"},\"keywords\":[\"fidelity\",\"TC-83\",\"V3526\",\"vaccine\",\"Venezuelan equine encephalitis virus\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2022\\\/01\\\/12\\\/venezuelan-equine-encephalitis-virus-v3526-vaccine-rna-dependent-rna-polymerase-mutants-increase-vaccine-safety-through-restricted-tissue-tropism-in-a-mouse-model\\\/\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2022\\\/01\\\/12\\\/venezuelan-equine-encephalitis-virus-v3526-vaccine-rna-dependent-rna-polymerase-mutants-increase-vaccine-safety-through-restricted-tissue-tropism-in-a-mouse-model\\\/\",\"name\":\"Venezuelan Equine Encephalitis Virus V3526 Vaccine RNA-Dependent RNA Polymerase Mutants Increase Vaccine Safety Through Restricted Tissue Tropism in a Mouse Model - 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Venezuelan equine encephalitis virus (VEEV) is an arbovirus endemic to the Americas, for which no vaccines or antiviral agents have been approved. TC-83 and V3526 are the best-characterized vaccine candidates for VEEV. 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