{"id":2319,"date":"2026-07-28T12:42:12","date_gmt":"2026-07-28T12:42:12","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=2319"},"modified":"2026-07-28T12:42:12","modified_gmt":"2026-07-28T12:42:12","slug":"ospc-bmpa-iclf-strip-borrelia-burgdorferi-canine","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2026\/07\/28\/ospc-bmpa-iclf-strip-borrelia-burgdorferi-canine\/","title":{"rendered":"Development of a Colloidal Gold Immunochromatographic Strip for Rapid Serological Detection of Antibodies to Borrelia burgdorferi in Canines"},"content":{"rendered":"

Announcing a new article publication for Zoonoses<\/em> journal. \u00a0This study was aimed at developing and preliminarily validating a colloidal gold immunochromatographic lateral flow (ICLF) strip for rapid serological screening of antibodies to\u00a0Borrelia burgdorferi<\/em>\u00a0in canine serum.<\/p>\n

An OspC-BmpA fusion antigen was expressed in\u00a0Escherichia coli<\/em>, purified, and used to assemble an antigen-based ICLF strip. Analytical performance was evaluated with serially diluted Enzyme-linked immunosorbent assay (ELISA)-positive serum, interferent-containing negative sera, stability and reproducibility testing, and 500 clinical canine sera tested in parallel with a comparator ELISA.<\/p>\n

The strip detected ELISA-positive control serum at a dilution as high as 1:64 under the tested visual interpretation conditions and showed no false-positive reactions in the tested interferent panel. Detectable performance was maintained after storage at 15\u201325\u00b0C for 12 months. Compared with ELISA, the strip showed a relative sensitivity of 91.00% (95% CI: 83.77\u201395.19%), relative specificity of 98.75% (95% CI: 97.11\u201399.46%), relative accuracy of 97.20% (95% CI: 95.36\u201398.32%), and Cohen\u2019s kappa coefficient of 0.911.<\/p>\n

The OspC-BmpA-based ICLF strip is a rapid and simple serological screening tool for detecting antibodies to\u00a0B. burgdorferi<\/em>\u00a0in dogs. Positive results should be interpreted together with clinical findings, exposure history, vaccination history, and confirmatory testing, when appropriate.<\/p>\n

Read More: https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2026-0041<\/a><\/p>\n

# # # # # #<\/strong><\/p>\n

Zoonoses<\/em> is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases. Please visit https:\/\/zoonoses-journal.org\/<\/a> to learn more about the journal.<\/p>\n

Zoonoses<\/em> is now open for submissions; articles can be submitted online at https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a><\/p>\n

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Editorial Board:<\/strong> https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n

Zoonoses<\/em><\/strong> is available on ScienceOpen<\/a> (https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700<\/a>).<\/p>\n

Follow Zoonoses <\/em><\/strong>on Twitter @ZoonosesJ<\/a>; Facebook<\/a> (https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114<\/a> ) and LinkedIn<\/a> (https:\/\/www.linkedin.com\/company\/zoonoses\/<\/a>)<\/p>\n

eISSN <\/strong>2737-7474<\/p>\n

ISSN<\/strong> 2737-7466<\/p>\n

# # # # # #<\/strong><\/p>\n

Jianzhong Wang, Yiduo Liu and Rui Zhou et al. Development of a Colloidal Gold Immunochromatographic Strip for Rapid Serological Detection of Antibodies to Borrelia burgdorferi in Canines.\u00a0Zoonoses.\u00a0<\/em>2026. Vol. 6(1). DOI: 10.15212\/ZOONOSES-2026-0041<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new article publication for Zoonoses journal. \u00a0This study was aimed at developing and preliminarily validating a colloidal gold immunochromatographic lateral flow (ICLF) strip for rapid serological screening of antibodies to\u00a0Borrelia burgdorferi\u00a0in canine serum. An OspC-BmpA fusion antigen was expressed in\u00a0Escherichia coli, purified, and used to assemble an antigen-based ICLF strip. Analytical performance was […]<\/p>\n","protected":false},"author":9,"featured_media":2322,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[790,788,791,673,789,792,116],"class_list":["post-2319","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-bmpa","tag-borrelia-burgdorferi","tag-caninehealth","tag-lymedisease","tag-ospc","tag-veterinarydiagnostics","tag-zoonosis"],"yoast_head":"\nDevelopment of a Colloidal Gold Immunochromatographic Strip for Rapid Serological Detection of Antibodies to Borrelia burgdorferi in Canines - Zoonoses Journal<\/title>\n<meta name=\"description\" content=\"The study introduces an OspC\u2011BmpA\u2011based ICLF strip as a rapid and straightforward serological tool for screening antibodies to Borrelia burgdorferi in dogs.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, 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