{"id":1752,"date":"2025-07-03T06:51:37","date_gmt":"2025-07-03T06:51:37","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=1752"},"modified":"2025-07-03T06:51:37","modified_gmt":"2025-07-03T06:51:37","slug":"vaccine-candidate-strain-coxsackievirus-b5","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2025\/07\/03\/vaccine-candidate-strain-coxsackievirus-b5\/","title":{"rendered":"A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties"},"content":{"rendered":"<p>Announcing a new article publication for <em>Zoonoses<\/em> journal. Evidence indicates that coxsackievirus B5 (CVB5) can cause meningitis, and hand, foot, and mouth disease (HFMD), and is associated with type 1 diabetes. No effective drug or vaccine is available for treating CVB5 infections or controlling outbreaks.<\/p>\n<p>The Vero-cell-adapted vaccine candidate strain KM299-L05 underwent comprehensive phylogenetic analysis, sequence alignment, assessment of virulence in BALB\/c mice, Vero cell acclimation, three successive rounds of plaque purification, preparation of experimental vaccines, and immunogenicity evaluation.<\/p>\n<p>KM299-L05 was the most virulent strain in BALB\/c mice. Its infectious titer reached 10<sup>8.0<\/sup>\u00a0CCID<sub>50<\/sub>\/mL in Vero cells, and it belonged to the Chinese epidemic genotype C3. An inactivated CVB5 vaccine derived from the KM299-L05 strain produced neutralizing antibodies with a titer range from 1:384 to 1:768 against a variety of clinical CVB5 isolates, particularly the prototype strain. Maternal antibodies fully protected all examined suckling BALB\/c mice against lethal challenge.<\/p>\n<p>Although the study was limited to neonatal mice, our findings suggested that the KM299-L05 strain has potential as a novel CVB5 vaccine candidate in China, and provide a rationale for the development of a CVB5 vaccine.<\/p>\n<p>VEEV was detected annually in 23.4% (128\/548) of the cases, while EEEV appeared intermittently (1.5% [8\/548]).<\/p>\n<p>Read full article: <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2025-0004\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2025-0004<\/a><\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p><em>Zoonoses<\/em> is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases. Please visit <a href=\"https:\/\/zoonoses-journal.org\/%20\">https:\/\/zoonoses-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><em>Zoonoses<\/em> is now open for submissions; articles can be submitted online at <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/\">https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p><strong><em>Zoonoses<\/em><\/strong> is available on <a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">ScienceOpen<\/a> (<a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700<\/a>).<\/p>\n<p>Follow <strong><em>Zoonoses <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/ZoonosesJ\">@ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114<\/a> ) and <a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">LinkedIn<\/a> (<a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">https:\/\/www.linkedin.com\/company\/zoonoses\/<\/a>)<strong>\u00a0<\/strong><\/p>\n<p><strong>eISSN <\/strong>2737-7474<\/p>\n<p><strong>ISSN<\/strong> 2737-7466<\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p>Yuhan Liu, Zhaoyang Chu and Ming Zhang et al. A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties.\u00a0<em>Zoonoses.\u00a0<\/em>2025. Vol. 5(1). DOI: 10.15212\/ZOONOSES-2025-0004<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new article publication for Zoonoses journal. Evidence indicates that coxsackievirus B5 (CVB5) can cause meningitis, and hand, foot, and mouth disease (HFMD), and is associated with type 1 diabetes. No effective drug or vaccine is available for treating CVB5 infections or controlling outbreaks. The Vero-cell-adapted vaccine candidate strain KM299-L05 underwent comprehensive phylogenetic analysis, [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":1753,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[637,635,52,179,636],"class_list":["post-1752","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-animal-model","tag-coxsackievirus-b5","tag-immunogenicity","tag-inactivated-vaccine","tag-vero-cell"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties - Zoonoses Journal<\/title>\n<meta name=\"description\" content=\"KM299-L05 strain has potential as a novel CVB5 vaccine candidate in China\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zoonoses-journal.org\/index.php\/2025\/07\/03\/vaccine-candidate-strain-coxsackievirus-b5\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties - Zoonoses Journal\" \/>\n<meta property=\"og:description\" content=\"KM299-L05 strain has potential as a novel CVB5 vaccine candidate in China\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zoonoses-journal.org\/index.php\/2025\/07\/03\/vaccine-candidate-strain-coxsackievirus-b5\/\" \/>\n<meta property=\"og:site_name\" content=\"Zoonoses Journal\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\" \/>\n<meta property=\"article:published_time\" content=\"2025-07-03T06:51:37+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2025\/07\/large-11.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"223\" \/>\n\t<meta property=\"og:image:height\" content=\"223\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Suresh Kumar\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:site\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Suresh Kumar\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/07\\\/03\\\/vaccine-candidate-strain-coxsackievirus-b5\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/07\\\/03\\\/vaccine-candidate-strain-coxsackievirus-b5\\\/\"},\"author\":{\"name\":\"Suresh Kumar\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/person\\\/32d651c0e99a7cc4ab2c74712d3b1d03\"},\"headline\":\"A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties\",\"datePublished\":\"2025-07-03T06:51:37+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/07\\\/03\\\/vaccine-candidate-strain-coxsackievirus-b5\\\/\"},\"wordCount\":366,\"publisher\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/07\\\/03\\\/vaccine-candidate-strain-coxsackievirus-b5\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/07\\\/large-11.jpg\",\"keywords\":[\"animal model\",\"coxsackievirus B5\",\"immunogenicity\",\"inactivated vaccine\",\"Vero cell\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/07\\\/03\\\/vaccine-candidate-strain-coxsackievirus-b5\\\/\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/07\\\/03\\\/vaccine-candidate-strain-coxsackievirus-b5\\\/\",\"name\":\"A New Vaccine Candidate Strain of Coxsackievirus B5 Selected on the Basis of its Biological Properties - 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