{"id":1734,"date":"2025-06-10T06:40:35","date_gmt":"2025-06-10T06:40:35","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=1734"},"modified":"2025-06-10T06:41:23","modified_gmt":"2025-06-10T06:41:23","slug":"mn-lnps-encapsulated-vzv-vaccine","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/","title":{"rendered":"Manganese-Coordinated Lipid Nanoparticles for Co-Delivery of VZV Antigen and CpG Adjuvant Enhance Vaccine Efficacy"},"content":{"rendered":"<p>Announcing a new article publication for <em>Zoonoses<\/em> journal. Because varicella zoster virus (VZV) infections are continually increasing, vaccine efficacy must be enhanced. To date, the inefficient in vivo utilization of antigens and adjuvants has limited vaccine-induced immune protection against VZV infection. Therefore, improving the antigen and adjuvant utilization efficiency is crucial to enhance VZV vaccine performance.<\/p>\n<p>To achieve favorable VZV antigen and adjuvant utilization efficiency, a co-delivery system was constructed based on manganese-coordinated lipid nanoparticles (Mn-LNPs). Palmitic acid was coordinated with manganese through hydrothermal synthesis. Furthermore, 1.6 molar palmitic acid-Mn was added to four commercial lipid nanoparticle components (SM-102:DSPC:CHO-HP:DSG-PEG2000 in a 50:10:37.5:2.5 molar ratio) to encapsulate VZV glycoprotein E (gE) antigen and CpG adjuvant by using a microfluidic chip. Mn-LNP size and morphology were characterised through transmission electron microscopy and quantified the manganese on palmitic acid-Mn through X-ray photoelectron spectroscopy. The performance of the Mn-LNP co-delivery system in enhancing VZV vaccine-induced immune responses was evaluated in a mouse model.<\/p>\n<p>The Mn-LNPs comprised positively charged spherical particles of approximately 270 nm in diameter, which encapsulated VZV gE antigen and CpG adjuvant in a 1:2 mass ratio. The Mn-LNP co-delivery system, compared with aluminium adjuvant, significantly enhanced VZV gE antigen-specific CD4<sup>+<\/sup>\u00a0and CD8<sup>+<\/sup>\u00a0T cell responses (1.47-fold and 5.66-fold enhanced IFN-\u03b3 response for CD4<sup>+<\/sup>\u00a0T cells and CD8<sup>+<\/sup>\u00a0T cells; 2.25-fold and 2.64-fold enhanced TNF-\u03b1 response for CD4<sup>+<\/sup>\u00a0T cells and CD8<sup>+<\/sup>\u00a0T cells; and 2.62-fold and 3.17-fold enhanced IL-2 response for CD4<sup>+<\/sup>\u00a0T cells and CD8<sup>+<\/sup>\u00a0T cells). Moreover, the Mn-LNPs, compared with commercial aluminium adjuvant, significantly enhanced the antigen-specific IgG2b subclass response.<\/p>\n<p>The Mn-LNP co-delivery system efficiently delivered both VZV antigen and CpG adjuvant, and markedly improved the VZV vaccine-induced T cell response. Thus, this Mn-LNP co-delivery system has promising potential in promoting VZV vaccine efficacy.<\/p>\n<p>Read full open access article: <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2024-0056\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2024-0056<\/a><\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p><em>Zoonoses<\/em> is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases. Please visit <a href=\"https:\/\/zoonoses-journal.org\/%20\">https:\/\/zoonoses-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><em>Zoonoses<\/em> is now open for submissions; articles can be submitted online at <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/\">https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p><strong><em>Zoonoses<\/em><\/strong> is available on <a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">ScienceOpen<\/a> (<a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700<\/a>).<\/p>\n<p>Follow <strong><em>Zoonoses <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/ZoonosesJ\">@ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114<\/a> ) and <a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">LinkedIn<\/a> (<a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">https:\/\/www.linkedin.com\/company\/zoonoses\/<\/a>)<\/p>\n<p><strong>\u00a0<\/strong><strong>eISSN <\/strong>2737-7474<\/p>\n<p><strong>ISSN<\/strong> 2737-7466<\/p>\n<p><strong># # # # # #<\/strong><\/p>\n<p>Liping Luo, Xinyue Deng and Jia Luo et al. Manganese-Coordinated Lipid Nanoparticles for Co-Delivery of VZV Antigen and CpG Adjuvant Enhance Vaccine Efficacy.\u00a0<em>Zoonoses.\u00a0<\/em>2025. Vol. 5(1). DOI: 10.15212\/ZOONOSES-2024-0056<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new article publication for Zoonoses journal. Because varicella zoster virus (VZV) infections are continually increasing, vaccine efficacy must be enhanced. To date, the inefficient in vivo utilization of antigens and adjuvants has limited vaccine-induced immune protection against VZV infection. Therefore, improving the antigen and adjuvant utilization efficiency is crucial to enhance VZV vaccine [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":1735,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[623,626,625,621,619,627,622,628,624,620],"class_list":["post-1734","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-adjuvant","tag-cpg-adjuvant","tag-glycoproteine-antigen","tag-immune-response","tag-lipid-nanoparticles","tag-t-cell-response","tag-vaccine-efficacy","tag-vaccine-induced-immune-response","tag-vzv-antigen","tag-vzv-vaccine"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Mn-LNP Co-Delivery System Enhances VZV Vaccine Efficacy<\/title>\n<meta name=\"description\" content=\"Mn-coordinated lipid nanoparticles (Mn-LNPs)-encapsulated varicella zoster virus (VZV) glycoprotein E antigen and CpG adjuvant enhances VZV vaccine efficacy.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Mn-LNP Co-Delivery System Enhances VZV Vaccine Efficacy\" \/>\n<meta property=\"og:description\" content=\"Mn-coordinated lipid nanoparticles (Mn-LNPs)-encapsulated varicella zoster virus (VZV) glycoprotein E antigen and CpG adjuvant enhances VZV vaccine efficacy.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/\" \/>\n<meta property=\"og:site_name\" content=\"Zoonoses Journal\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\" \/>\n<meta property=\"article:published_time\" content=\"2025-06-10T06:40:35+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2025-06-10T06:41:23+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2025\/06\/Manganese-Coordinated-Lipid-Nanoparticles.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1200\" \/>\n\t<meta property=\"og:image:height\" content=\"628\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Suresh Kumar\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:site\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Suresh Kumar\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"3 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/\"},\"author\":{\"name\":\"Suresh Kumar\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/person\\\/32d651c0e99a7cc4ab2c74712d3b1d03\"},\"headline\":\"Manganese-Coordinated Lipid Nanoparticles for Co-Delivery of VZV Antigen and CpG Adjuvant Enhance Vaccine Efficacy\",\"datePublished\":\"2025-06-10T06:40:35+00:00\",\"dateModified\":\"2025-06-10T06:41:23+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/\"},\"wordCount\":459,\"publisher\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/Manganese-Coordinated-Lipid-Nanoparticles.jpg\",\"keywords\":[\"adjuvant\",\"CpG adjuvant\",\"glycoproteinE antigen\",\"immune response\",\"Lipid nanoparticles\",\"T-cell response\",\"vaccine efficacy\",\"vaccine-induced immune response\",\"VZV antigen\",\"VZV vaccine\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/\",\"name\":\"Mn-LNP Co-Delivery System Enhances VZV Vaccine Efficacy\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/Manganese-Coordinated-Lipid-Nanoparticles.jpg\",\"datePublished\":\"2025-06-10T06:40:35+00:00\",\"dateModified\":\"2025-06-10T06:41:23+00:00\",\"description\":\"Mn-coordinated lipid nanoparticles (Mn-LNPs)-encapsulated varicella zoster virus (VZV) glycoprotein E antigen and CpG adjuvant enhances VZV vaccine efficacy.\",\"breadcrumb\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/\"]}]},{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/#primaryimage\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/Manganese-Coordinated-Lipid-Nanoparticles.jpg\",\"contentUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2025\\\/06\\\/Manganese-Coordinated-Lipid-Nanoparticles.jpg\",\"width\":1200,\"height\":628,\"caption\":\"Manganese-Coordinated Lipid Nanoparticles for Co-Delivery of VZV Antigen Vaccine\"},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2025\\\/06\\\/10\\\/mn-lnps-encapsulated-vzv-vaccine\\\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\\\/\\\/zoonoses-journal.org\\\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Manganese-Coordinated Lipid Nanoparticles for Co-Delivery of VZV Antigen and CpG Adjuvant Enhance Vaccine Efficacy\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#website\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/\",\"name\":\"Zoonoses Journal\",\"description\":\"\",\"publisher\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\"},\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\\\/\\\/zoonoses-journal.org\\\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"},{\"@type\":\"Organization\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\",\"name\":\"Zoonoses Journal\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/\",\"logo\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/logo\\\/image\\\/\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/cropped-cropped-Zoonoses_logo_small-1.png\",\"contentUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2021\\\/03\\\/cropped-cropped-Zoonoses_logo_small-1.png\",\"width\":512,\"height\":512,\"caption\":\"Zoonoses Journal\"},\"image\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/logo\\\/image\\\/\"},\"sameAs\":[\"https:\\\/\\\/www.facebook.com\\\/Zoonoses-Journal-100462755574114\",\"https:\\\/\\\/x.com\\\/ZoonosesJ\",\"https:\\\/\\\/www.linkedin.com\\\/company\\\/78022634\"]},{\"@type\":\"Person\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/person\\\/32d651c0e99a7cc4ab2c74712d3b1d03\",\"name\":\"Suresh Kumar\",\"image\":{\"@type\":\"ImageObject\",\"inLanguage\":\"en-US\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/litespeed\\\/avatar\\\/3f8350109df89aa7dbb6d16dc7a4506c.jpg?ver=1774976001\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/litespeed\\\/avatar\\\/3f8350109df89aa7dbb6d16dc7a4506c.jpg?ver=1774976001\",\"contentUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/litespeed\\\/avatar\\\/3f8350109df89aa7dbb6d16dc7a4506c.jpg?ver=1774976001\",\"caption\":\"Suresh Kumar\"},\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/author\\\/suresh\\\/\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Mn-LNP Co-Delivery System Enhances VZV Vaccine Efficacy","description":"Mn-coordinated lipid nanoparticles (Mn-LNPs)-encapsulated varicella zoster virus (VZV) glycoprotein E antigen and CpG adjuvant enhances VZV vaccine efficacy.","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/","og_locale":"en_US","og_type":"article","og_title":"Mn-LNP Co-Delivery System Enhances VZV Vaccine Efficacy","og_description":"Mn-coordinated lipid nanoparticles (Mn-LNPs)-encapsulated varicella zoster virus (VZV) glycoprotein E antigen and CpG adjuvant enhances VZV vaccine efficacy.","og_url":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/","og_site_name":"Zoonoses Journal","article_publisher":"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114","article_published_time":"2025-06-10T06:40:35+00:00","article_modified_time":"2025-06-10T06:41:23+00:00","og_image":[{"width":1200,"height":628,"url":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2025\/06\/Manganese-Coordinated-Lipid-Nanoparticles.jpg","type":"image\/jpeg"}],"author":"Suresh Kumar","twitter_card":"summary_large_image","twitter_creator":"@ZoonosesJ","twitter_site":"@ZoonosesJ","twitter_misc":{"Written by":"Suresh Kumar","Est. reading time":"3 minutes"},"schema":{"@context":"https:\/\/schema.org","@graph":[{"@type":"Article","@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/#article","isPartOf":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/"},"author":{"name":"Suresh Kumar","@id":"https:\/\/zoonoses-journal.org\/#\/schema\/person\/32d651c0e99a7cc4ab2c74712d3b1d03"},"headline":"Manganese-Coordinated Lipid Nanoparticles for Co-Delivery of VZV Antigen and CpG Adjuvant Enhance Vaccine Efficacy","datePublished":"2025-06-10T06:40:35+00:00","dateModified":"2025-06-10T06:41:23+00:00","mainEntityOfPage":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/"},"wordCount":459,"publisher":{"@id":"https:\/\/zoonoses-journal.org\/#organization"},"image":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/#primaryimage"},"thumbnailUrl":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2025\/06\/Manganese-Coordinated-Lipid-Nanoparticles.jpg","keywords":["adjuvant","CpG adjuvant","glycoproteinE antigen","immune response","Lipid nanoparticles","T-cell response","vaccine efficacy","vaccine-induced immune response","VZV antigen","VZV vaccine"],"articleSection":["News and Events"],"inLanguage":"en-US"},{"@type":"WebPage","@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/","url":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/","name":"Mn-LNP Co-Delivery System Enhances VZV Vaccine Efficacy","isPartOf":{"@id":"https:\/\/zoonoses-journal.org\/#website"},"primaryImageOfPage":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/#primaryimage"},"image":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/#primaryimage"},"thumbnailUrl":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2025\/06\/Manganese-Coordinated-Lipid-Nanoparticles.jpg","datePublished":"2025-06-10T06:40:35+00:00","dateModified":"2025-06-10T06:41:23+00:00","description":"Mn-coordinated lipid nanoparticles (Mn-LNPs)-encapsulated varicella zoster virus (VZV) glycoprotein E antigen and CpG adjuvant enhances VZV vaccine efficacy.","breadcrumb":{"@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/#breadcrumb"},"inLanguage":"en-US","potentialAction":[{"@type":"ReadAction","target":["https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/"]}]},{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/#primaryimage","url":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2025\/06\/Manganese-Coordinated-Lipid-Nanoparticles.jpg","contentUrl":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2025\/06\/Manganese-Coordinated-Lipid-Nanoparticles.jpg","width":1200,"height":628,"caption":"Manganese-Coordinated Lipid Nanoparticles for Co-Delivery of VZV Antigen Vaccine"},{"@type":"BreadcrumbList","@id":"https:\/\/zoonoses-journal.org\/index.php\/2025\/06\/10\/mn-lnps-encapsulated-vzv-vaccine\/#breadcrumb","itemListElement":[{"@type":"ListItem","position":1,"name":"Home","item":"https:\/\/zoonoses-journal.org\/"},{"@type":"ListItem","position":2,"name":"Manganese-Coordinated Lipid Nanoparticles for Co-Delivery of VZV Antigen and CpG Adjuvant Enhance Vaccine Efficacy"}]},{"@type":"WebSite","@id":"https:\/\/zoonoses-journal.org\/#website","url":"https:\/\/zoonoses-journal.org\/","name":"Zoonoses Journal","description":"","publisher":{"@id":"https:\/\/zoonoses-journal.org\/#organization"},"potentialAction":[{"@type":"SearchAction","target":{"@type":"EntryPoint","urlTemplate":"https:\/\/zoonoses-journal.org\/?s={search_term_string}"},"query-input":{"@type":"PropertyValueSpecification","valueRequired":true,"valueName":"search_term_string"}}],"inLanguage":"en-US"},{"@type":"Organization","@id":"https:\/\/zoonoses-journal.org\/#organization","name":"Zoonoses Journal","url":"https:\/\/zoonoses-journal.org\/","logo":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/zoonoses-journal.org\/#\/schema\/logo\/image\/","url":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2021\/03\/cropped-cropped-Zoonoses_logo_small-1.png","contentUrl":"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2021\/03\/cropped-cropped-Zoonoses_logo_small-1.png","width":512,"height":512,"caption":"Zoonoses Journal"},"image":{"@id":"https:\/\/zoonoses-journal.org\/#\/schema\/logo\/image\/"},"sameAs":["https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114","https:\/\/x.com\/ZoonosesJ","https:\/\/www.linkedin.com\/company\/78022634"]},{"@type":"Person","@id":"https:\/\/zoonoses-journal.org\/#\/schema\/person\/32d651c0e99a7cc4ab2c74712d3b1d03","name":"Suresh Kumar","image":{"@type":"ImageObject","inLanguage":"en-US","@id":"https:\/\/zoonoses-journal.org\/wp-content\/litespeed\/avatar\/3f8350109df89aa7dbb6d16dc7a4506c.jpg?ver=1774976001","url":"https:\/\/zoonoses-journal.org\/wp-content\/litespeed\/avatar\/3f8350109df89aa7dbb6d16dc7a4506c.jpg?ver=1774976001","contentUrl":"https:\/\/zoonoses-journal.org\/wp-content\/litespeed\/avatar\/3f8350109df89aa7dbb6d16dc7a4506c.jpg?ver=1774976001","caption":"Suresh Kumar"},"url":"https:\/\/zoonoses-journal.org\/index.php\/author\/suresh\/"}]}},"_links":{"self":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1734","targetHints":{"allow":["GET"]}}],"collection":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/users\/6"}],"replies":[{"embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/comments?post=1734"}],"version-history":[{"count":2,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1734\/revisions"}],"predecessor-version":[{"id":1737,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/posts\/1734\/revisions\/1737"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/media\/1735"}],"wp:attachment":[{"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/media?parent=1734"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/categories?post=1734"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/zoonoses-journal.org\/index.php\/wp-json\/wp\/v2\/tags?post=1734"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}