{"id":1620,"date":"2025-01-29T12:09:13","date_gmt":"2025-01-29T12:09:13","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=1620"},"modified":"2025-01-29T12:36:30","modified_gmt":"2025-01-29T12:36:30","slug":"gyrb-mutation-in-staphylococcus-aureus","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2025\/01\/29\/gyrb-mutation-in-staphylococcus-aureus\/","title":{"rendered":"Metabolic Analysis of the Mode of Action and Mode of Resistance for Novobiocin in Staphylococcus aureus"},"content":{"rendered":"

Announcing a new article publication for Zoonoses<\/em> journal<\/a>. Methicillin resistant\u00a0Staphylococcus aureus<\/em>\u00a0(MRSA) and Vancomycin resistant\u00a0Staphylococcus aureus<\/em>\u00a0(VRSA) are critical pathogens identified by the WHO for their significant drug resistance. Targeting of bacterial gyrase, specifically the gyrB subunit, is a promising approach because of this enzyme\u2019s essential role in bacterial DNA replication and its absence in higher eukaryotes.<\/p>\n

However, understanding of the mode of action of gyrB inhibitors remains largely incomplete. This study explored the resistance mechanisms of\u00a0Staphylococcus aureus<\/em>\u00a0(S. aureus<\/em>) to novobiocin, a gyrB inhibitor.<\/p>\n

Through adaptive laboratory evolution, key resistance mutations (in gyrB, potB, and fpgS) in\u00a0S. aureus<\/em>\u00a0were identified after repeated exposure to novobiocin. Further metabolomic analysis revealed the function of the major mutation (in gyrB) in relation to the potential mechanism through which\u00a0S. aureus<\/em>\u00a0responds to novobiocin.<\/p>\n

Through whole genome sequencing, three mutations of\u00a0S. aureus<\/em>\u00a0in gyrB, potB, and fpgS were identified. The gyrB mutation was the primary driver of resistance, and was associated with changes in growth, survival under surface and oxidative stress, cell wall permeability, and coagulation functions. Metabolomic analysis demonstrated compensatory metabolic adjustments affecting protein synthesis and DNA replication in the resistant strain.<\/p>\n

These findings provide insights into the complex resistance mechanisms of\u00a0S. aureus<\/em>\u00a0to novobiocin and highlight the metabolic costs associated with gyrB mutations, thereby potentially informing future antibacterial strategy development.<\/p>\n

Read More:\u00a0https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2024-0035<\/a><\/p>\n

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eISSN <\/strong>2737-7474<\/p>\n

ISSN<\/strong> 2737-7466<\/p>\n

Weile Xie, Dan Luo and Zhe Wang. Metabolic Analysis of the Mode of Action and Mode of Resistance for Novobiocin in Staphylococcus aureus.\u00a0Zoonoses.\u00a0<\/em>2025. Vol. 5(1). DOI: 10.15212\/ZOONOSES-2024-0035<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new article publication for Zoonoses journal. Methicillin resistant\u00a0Staphylococcus aureus\u00a0(MRSA) and Vancomycin resistant\u00a0Staphylococcus aureus\u00a0(VRSA) are critical pathogens identified by the WHO for their significant drug resistance. Targeting of bacterial gyrase, specifically the gyrB subunit, is a promising approach because of this enzyme\u2019s essential role in bacterial DNA replication and its absence in higher eukaryotes. […]<\/p>\n","protected":false},"author":5,"featured_media":1623,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[479,533,535,534],"class_list":["post-1620","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-drug-resistance","tag-gyrb-mutation-in-staphylococcus-aureus","tag-metabolomics","tag-novobiocin"],"yoast_head":"\nMetabolic Analysis of the Mode of Action and Mode of Resistance for Novobiocin in Staphylococcus aureus<\/title>\n<meta name=\"description\" content=\"This study explores gyrB mutation in Staphylococcus aureus, revealing resistance mechanisms to novobiocin and its impact on metabolism and cell functions.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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