{"id":1471,"date":"2024-09-10T07:10:05","date_gmt":"2024-09-10T07:10:05","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=1471"},"modified":"2024-09-10T07:10:05","modified_gmt":"2024-09-10T07:10:05","slug":"prospects-and-challenges-of-genetically-modified-live-attenuated-leishmania-vaccines","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2024\/09\/10\/prospects-and-challenges-of-genetically-modified-live-attenuated-leishmania-vaccines\/","title":{"rendered":"Prospects and Challenges of Genetically Modified Live-Attenuated Leishmania Vaccines"},"content":{"rendered":"

Announcing a new article publication for Zoonoses<\/em> journal<\/a>. Leishmaniases are transmitted by the protozoan parasite\u00a0Leishmania<\/em> through the bites of infected sandflies. Despite the availability of various medications, rising resistance and toxicity levels underscore the urgent need to explore and create a reliable, safe Leishmania vaccines for human use. Creating live attenuated promastigotes by genetically modifying essential gene targets affects their virulence without influencing their immunogenic attribution, and has shown highly promising reproducibility. These vaccines provide protection against challenge with virulent wild-type parasites.<\/p>\n

Advances in CRISPR\/Cas9 gene editing technology have shown promise in enabling marker-free gene modification. This articles discusses genetically modified\u00a0Leishmania<\/em>\u00a0with the potential to confer protection against wild-type\u00a0Leishmania<\/em>\u00a0challenge in animal models. Because of several limitations, success has not been achieved to date. Therefore, additional potential candidates with high effectiveness must be assessed as potential vaccines in the future.<\/p>\n

Read More:\u00a0https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2024-0010<\/a><\/p>\n

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eISSN <\/strong>2737-7474<\/p>\n

ISSN<\/strong> 2737-7466<\/p>\n

Suman Karmakar, Mousumi Das and Monalisa Ray et al. Prospects and Challenges of Genetically Modified Live-Attenuated Leishmania Vaccines.\u00a0Zoonoses.\u00a0<\/em>2024. Vol. 4(1). DOI: 10.15212\/ZOONOSES-2024-0010<\/p>\n","protected":false},"excerpt":{"rendered":"

Announcing a new article publication for Zoonoses journal. Leishmaniases are transmitted by the protozoan parasite\u00a0Leishmania through the bites of infected sandflies. Despite the availability of various medications, rising resistance and toxicity levels underscore the urgent need to explore and create a reliable, safe Leishmania vaccines for human use. Creating live attenuated promastigotes by genetically modifying […]<\/p>\n","protected":false},"author":5,"featured_media":1472,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[484,483,482,56],"class_list":["post-1471","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-attenuated","tag-knockout","tag-leishmania","tag-vaccine"],"yoast_head":"\nProspects and Challenges of Genetically Modified Live-Attenuated Leishmania Vaccines<\/title>\n<meta name=\"description\" content=\"Leishmaniases are transmitted by the protozoan parasite Leishmania through the bites of infected sandflies. 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