{"id":1439,"date":"2024-08-16T07:43:16","date_gmt":"2024-08-16T07:43:16","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=1439"},"modified":"2024-09-10T06:01:26","modified_gmt":"2024-09-10T06:01:26","slug":"enhanced-expression-of-two-isgs-as-potential-biomarkers-of-prognosis-in-hiv-infected-immunological-non-responders","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2024\/08\/16\/enhanced-expression-of-two-isgs-as-potential-biomarkers-of-prognosis-in-hiv-infected-immunological-non-responders\/","title":{"rendered":"Enhanced Expression of Two ISGs as Potential Biomarkers of Prognosis in HIV-Infected Immunological Non-Responders"},"content":{"rendered":"<p>Announcing a new article publication for <em>Zoonoses<\/em> journal. No novel biomarkers are currently available for evaluating immune reconstitution among people living with HIV\/AIDS (PLWH) receiving combined antiretroviral treatment (cART). This study analyzed the expression patterns of interferon-stimulating genes (ISGs) in PLWH with the aim of identifying potential biomarkers for immune reconstitution.<\/p>\n<p>Study samples were collected from 102 PLWH, including 47 immunological non-responders (INRs) and 58 immunological responders (IRs). The expression of eight ISGs in the peripheral blood in INRs and IRs were detected by RT-qPCR. Expression differences between groups were analyzed with the Mann-Whitney U test, and a logistic regression model was developed to predict immune reconstitution.<\/p>\n<p>Among eight ISGs, the expression levels of IFI27 and IFI6 were significantly higher in INRs than IRs (<em>P<\/em>=0.001 and 0.005, respectively). The model combining age, CD4<sup>+<\/sup>\u00a0T\/CD8<sup>+<\/sup>\u00a0T ratio, IFI27, and IFI6 had the highest diagnostic value (AUC=0.836), with an optimal cut-off value of 0.6, sensitivity of 60.5%, and specificity of 98.1%. No significant change in the expression of IFI27 and IFI6 was observed in samples collected 3 years apart (<em>P<\/em>=0.1232 and 0.4877, respectively), and the model score negatively correlated with \u0394CD4<sup>+<\/sup>\u00a0T cells (r=\u22120.2888,\u00a0<em>P<\/em>=0.0465).<\/p>\n<p>Enhanced expression of IFI27 and IFI6 in INRs are important characteristics that may serve as biomarkers of immune reconstitution after cART. The combination of age, CD4<sup>+<\/sup>\u00a0T\/CD8<sup>+<\/sup>\u00a0T ratio, IFI27, and IFI6 was highly effective in discriminating INRs.<\/p>\n<p>Read full article: <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2024-0016\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2024-0016<\/a><\/p>\n<p><em>Zoonoses<\/em> is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases. Please visit <a href=\"https:\/\/zoonoses-journal.org\/%20\">https:\/\/zoonoses-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><em>Zoonoses<\/em> is now open for submissions; articles can be submitted online at <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a><\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/\">https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p><strong><em>\u00a0<\/em><\/strong><strong><em>Zoonoses<\/em><\/strong> is available on <a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">ScienceOpen<\/a> (<a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700<\/a>).<\/p>\n<p>Follow <strong><em>Zoonoses <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/ZoonosesJ\">@ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114<\/a> ) and <a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">LinkedIn<\/a> (<a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">https:\/\/www.linkedin.com\/company\/zoonoses\/<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7474<\/p>\n<p><strong>ISSN<\/strong> 2737-7466<\/p>\n<p>Xin Zhang, Lin He and Ruifeng Zhang et al. Enhanced Expression of Two ISGs as Potential Biomarkers of Prognosis in HIV-Infected Immunological Non-Responders.\u00a0<em>Zoonoses.\u00a0<\/em>2024. Vol. 4(1). DOI: 10.15212\/ZOONOSES-2024-0016<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new article publication for Zoonoses journal. No novel biomarkers are currently available for evaluating immune reconstitution among people living with HIV\/AIDS (PLWH) receiving combined antiretroviral treatment (cART). This study analyzed the expression patterns of interferon-stimulating genes (ISGs) in PLWH with the aim of identifying potential biomarkers for immune reconstitution. Study samples were collected [&hellip;]<\/p>\n","protected":false},"author":6,"featured_media":1440,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[476,472,477,473,474,475,478],"class_list":["post-1439","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-combined-antiretroviral-treatment","tag-hiv-infection","tag-hiv-aids","tag-immune-reconstitution","tag-immunological-non-responder","tag-interferon-stimulated-genes","tag-interferon-stimulating-genes"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.3 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>Enhanced Expression of Two ISGs as Potential Biomarkers of Prognosis in HIV-Infected Immunological Non-Responders<\/title>\n<meta name=\"description\" content=\"This study analyzed the expression patterns of interferon-stimulating genes (ISGs) in PLWH with the aim of identifying potential biomarkers for immune reconstitution.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zoonoses-journal.org\/index.php\/2024\/08\/16\/enhanced-expression-of-two-isgs-as-potential-biomarkers-of-prognosis-in-hiv-infected-immunological-non-responders\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Enhanced Expression of Two ISGs as Potential Biomarkers of Prognosis in HIV-Infected Immunological Non-Responders\" \/>\n<meta property=\"og:description\" content=\"This study analyzed the expression patterns of interferon-stimulating genes (ISGs) in PLWH with the aim of identifying potential biomarkers for immune reconstitution.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zoonoses-journal.org\/index.php\/2024\/08\/16\/enhanced-expression-of-two-isgs-as-potential-biomarkers-of-prognosis-in-hiv-infected-immunological-non-responders\/\" \/>\n<meta property=\"og:site_name\" content=\"Zoonoses Journal\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\" \/>\n<meta property=\"article:published_time\" content=\"2024-08-16T07:43:16+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-09-10T06:01:26+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2024\/08\/Enhanced-Expression-of-Two-ISGs-as-Potential-Biomarkers-of-Prognosis-in-HIV.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"800\" \/>\n\t<meta property=\"og:image:height\" content=\"418\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Suresh Kumar\" \/>\n<meta name=\"twitter:card\" 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