{"id":1144,"date":"2023-11-14T09:15:02","date_gmt":"2023-11-14T09:15:02","guid":{"rendered":"https:\/\/zoonoses-journal.org\/?p=1144"},"modified":"2024-08-27T10:22:22","modified_gmt":"2024-08-27T10:22:22","slug":"na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice","status":"publish","type":"post","link":"https:\/\/zoonoses-journal.org\/index.php\/2023\/11\/14\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\/","title":{"rendered":"NA N342K Mutation Enhances the Pathogenicity of Influenza B Virus in Mice"},"content":{"rendered":"<p>Announcing a new article publication for <a href=\"https:\/\/zoonoses-journal.org\/\"><em>Zoonoses<\/em> journal<\/a>. Influenza B virus is a significant respiratory pathogen responsible for seasonal influenza. In recent years the B\/Yamagata lineage has demonstrated a rapid increase, predominantly featuring the neuraminidase (NA)<sub>N342K<\/sub>\u00a0mutation. This study determined the impact of the NA<sub>N342K<\/sub>\u00a0mutation on the pathogenicity of influenza B virus and elucidate the underlying mechanisms.<\/p>\n<p>Gene fragments with specific mutations were generated using site-directed mutagenesis PCR, resulting in recombinant viruses (rAH127 and rAH127\/NA<sub>N342K<\/sub>). C57BL\/6 mice were infected to evaluate the impact of amino acid mutations on virus pathogenicity. Body weight, survival rate, virus replication, and lung pathology were compared among the groups. NA enzyme activity was assessed to determine the mechanisms underlying the effects of amino acid mutations on the pathogenicity of influenza B virus.<\/p>\n<p>The NA<sub>N342K<\/sub>\u00a0mutant virus exhibited significantly increased NA enzyme activity (3.19-fold) and viral replication capacity in MDCK cells (6.76-fold) compared to wild-type virus. These changes led to enhanced pathogenicity in mice, characterized by severe weight loss, increased mortality, and heightened lung tissue inflammation.<\/p>\n<p>The NA<sub>N342K<\/sub>\u00a0mutation likely enhances virus replication and pathogenicity by increasing NA enzyme activity. These findings contribute to understanding the molecular mechanisms underlying influenza B virus pathogenicity and have implications for targeted therapeutic strategies.<\/p>\n<p>Read More: <a href=\"https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2023-0013\">https:\/\/www.scienceopen.com\/hosted-document?doi=10.15212\/ZOONOSES-2023-0013<\/a><\/p>\n<p><a href=\"https:\/\/zoonoses-journal.org\/\"><em>Zoonoses<\/em><\/a> is fully open access journal for research scientists, physicians, veterinarians, and public health professionals working on diverse disciplinaries of zoonotic diseases.<\/p>\n<p><em>Zoonoses<\/em> is now open for submissions; articles can be submitted online at <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a><\/p>\n<p>Please visit <a href=\"https:\/\/zoonoses-journal.org\/%20\">https:\/\/zoonoses-journal.org\/<\/a> to learn more about the journal.<\/p>\n<p><strong>Editorial Board:<\/strong> <a href=\"https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/\">https:\/\/zoonoses-journal.org\/index.php\/editorial-board\/<\/a><\/p>\n<p><strong><em>Zoonoses<\/em><\/strong> is available on <a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">ScienceOpen<\/a> (<a href=\"https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700\">https:\/\/www.scienceopen.com\/search#collection\/839df240-327f-47dd-b636-9b728dff9700<\/a>).<\/p>\n<p>Submissions may be made using <a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">ScholarOne<\/a> (<a href=\"https:\/\/mc04.manuscriptcentral.com\/zoonoses\">https:\/\/mc04.manuscriptcentral.com\/zoonoses<\/a>).<\/p>\n<p>There are no author submission or article processing fees.<\/p>\n<p>Follow <strong><em>Zoonoses <\/em><\/strong>on Twitter <a href=\"https:\/\/twitter.com\/ZoonosesJ\">@ZoonosesJ<\/a>; <a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">Facebook<\/a> (<a href=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\">https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114<\/a> ) and <a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">LinkedIn<\/a> (<a href=\"https:\/\/www.linkedin.com\/company\/zoonoses\/\">https:\/\/www.linkedin.com\/company\/zoonoses\/<\/a>)<\/p>\n<p><strong>eISSN <\/strong>2737-7474<\/p>\n<p><strong>ISSN<\/strong> 2737-7466<\/p>\n<p>Qi Chen, Xiaohao Xu and Min Tan et al. NAN342K Mutation Enhances the Pathogenicity of Influenza B Virus in Mice.\u00a0<em>Zoonoses.\u00a0<\/em>2023. Vol. 3(1). DOI: 10.15212\/ZOONOSES-2023-0013<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Announcing a new article publication for Zoonoses journal. Influenza B virus is a significant respiratory pathogen responsible for seasonal influenza. In recent years the B\/Yamagata lineage has demonstrated a rapid increase, predominantly featuring the neuraminidase (NA)N342K\u00a0mutation. This study determined the impact of the NAN342K\u00a0mutation on the pathogenicity of influenza B virus and elucidate the underlying [&hellip;]<\/p>\n","protected":false},"author":5,"featured_media":1455,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":{"footnotes":""},"categories":[6],"tags":[20,340,342,341],"class_list":["post-1144","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-news-and-events","tag-epidemiology","tag-influenza-b-virus","tag-neuraminidase","tag-pathogenicity"],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v27.4 - https:\/\/yoast.com\/product\/yoast-seo-wordpress\/ -->\n<title>NA N342K Mutation Enhances the Pathogenicity of Influenza B Virus in Mice - Zoonoses Journal<\/title>\n<meta name=\"description\" content=\"Influenza B virus is a significant respiratory pathogen responsible for seasonal influenza. In recent years the B\/Yamagata lineage has demonstrated a rapid increase, predominantly featuring the neuraminidase (NA)N342K\u00a0mutation. This study determined the impact of the NAN342K\u00a0mutation on the pathogenicity of influenza B virus and elucidate the underlying mechanisms.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/zoonoses-journal.org\/index.php\/2023\/11\/14\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"NA N342K Mutation Enhances the Pathogenicity of Influenza B Virus in Mice - Zoonoses Journal\" \/>\n<meta property=\"og:description\" content=\"Influenza B virus is a significant respiratory pathogen responsible for seasonal influenza. In recent years the B\/Yamagata lineage has demonstrated a rapid increase, predominantly featuring the neuraminidase (NA)N342K\u00a0mutation. This study determined the impact of the NAN342K\u00a0mutation on the pathogenicity of influenza B virus and elucidate the underlying mechanisms.\" \/>\n<meta property=\"og:url\" content=\"https:\/\/zoonoses-journal.org\/index.php\/2023\/11\/14\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\/\" \/>\n<meta property=\"og:site_name\" content=\"Zoonoses Journal\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/Zoonoses-Journal-100462755574114\" \/>\n<meta property=\"article:published_time\" content=\"2023-11-14T09:15:02+00:00\" \/>\n<meta property=\"article:modified_time\" content=\"2024-08-27T10:22:22+00:00\" \/>\n<meta property=\"og:image\" content=\"https:\/\/zoonoses-journal.org\/wp-content\/uploads\/2023\/11\/NA-N342K-Mutation-Enhances-the-Pathogenicity-of-Influenza-B-Virus-in-Mice.jpg\" \/>\n\t<meta property=\"og:image:width\" content=\"1862\" \/>\n\t<meta property=\"og:image:height\" content=\"1138\" \/>\n\t<meta property=\"og:image:type\" content=\"image\/jpeg\" \/>\n<meta name=\"author\" content=\"Pdrtiru\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:creator\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:site\" content=\"@ZoonosesJ\" \/>\n<meta name=\"twitter:label1\" content=\"Written by\" \/>\n\t<meta name=\"twitter:data1\" content=\"Pdrtiru\" \/>\n\t<meta name=\"twitter:label2\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data2\" content=\"2 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\\\/\\\/schema.org\",\"@graph\":[{\"@type\":\"Article\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/11\\\/14\\\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\\\/#article\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/11\\\/14\\\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\\\/\"},\"author\":{\"name\":\"Pdrtiru\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#\\\/schema\\\/person\\\/7b94348b9f4f5d3983636ac0a201853f\"},\"headline\":\"NA N342K Mutation Enhances the Pathogenicity of Influenza B Virus in Mice\",\"datePublished\":\"2023-11-14T09:15:02+00:00\",\"dateModified\":\"2024-08-27T10:22:22+00:00\",\"mainEntityOfPage\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/11\\\/14\\\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\\\/\"},\"wordCount\":382,\"publisher\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#organization\"},\"image\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/11\\\/14\\\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2023\\\/11\\\/NA-N342K-Mutation-Enhances-the-Pathogenicity-of-Influenza-B-Virus-in-Mice.jpg\",\"keywords\":[\"epidemiology\",\"influenza B virus\",\"neuraminidase\",\"pathogenicity\"],\"articleSection\":[\"News and Events\"],\"inLanguage\":\"en-US\"},{\"@type\":\"WebPage\",\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/11\\\/14\\\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\\\/\",\"url\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/11\\\/14\\\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\\\/\",\"name\":\"NA N342K Mutation Enhances the Pathogenicity of Influenza B Virus in Mice - Zoonoses Journal\",\"isPartOf\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/#website\"},\"primaryImageOfPage\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/11\\\/14\\\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\\\/#primaryimage\"},\"image\":{\"@id\":\"https:\\\/\\\/zoonoses-journal.org\\\/index.php\\\/2023\\\/11\\\/14\\\/na-n342k-mutation-enhances-the-pathogenicity-of-influenza-b-virus-in-mice\\\/#primaryimage\"},\"thumbnailUrl\":\"https:\\\/\\\/zoonoses-journal.org\\\/wp-content\\\/uploads\\\/2023\\\/11\\\/NA-N342K-Mutation-Enhances-the-Pathogenicity-of-Influenza-B-Virus-in-Mice.jpg\",\"datePublished\":\"2023-11-14T09:15:02+00:00\",\"dateModified\":\"2024-08-27T10:22:22+00:00\",\"description\":\"Influenza B virus is a significant respiratory pathogen responsible for seasonal influenza. 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