The “hygiene hypothesis” suggests that reduced pathogen exposures during early life leads to an imbalance of the immune system. The epidemiological studies were conducted supporting this concept that some zoonotic parasites infections (e.g. Schistosoma, Hookworm), which are characterized by the predominated induction of strong type 2 immune responses or regulatory T cell response, correlate with a decreased prevalence of intestinal inflammatory diseases, obesity, and allergic diseases, etc. A better understanding of these underline mechanisms is critical for their therapeutic implications.
Innate immunity occurs immediately while adaptive immunity develops upon pathogen exposure, and is long-lasting, highly specific, and sustained by memory T cells. Looking for the application value of new genes, molecules and drugs based on parasites is critical for the development of translational medicine, and it is particularly important to explore the immunological mechanisms of such molecules and drugs.
This thematic series aims to present the latest findings in pathogen-derived molecules and innovative therapies and diagnostics involving in various diseases, including cancer, diabetes, obesity and hepatic disease, etc. We solicit high-quality original research articles as well as review articles focusing on providing new ideas and scientific theoretical basis for the diagnosis and treatment of immune-related diseases based on parasitic infections.
We welcome submissions of original research, review, mini review, hypothesis and theory, focusing on the following aspects:
- Epidemiology, diagnosis, treatment and vaccine development of zoonotic parasitic diseases
- Identification of novel pathogen-derived molecules in the immune response elicited by zoonotic parasitic infections
- Potential diagnostic and prognostic markers for zoonotic parasitic diseases
- Treatment of various diseases based on pathogen-derived molecules, including protein, miRNA and extracellular vesicles (EVs), etc.
- Host-parasites interactions
- AI and deep learning in management of zoonotic parasitic diseases
|Zhipeng Xu, Ph.D.,
Department of Pathogen Biology, Nanjing Medical University; Jiangsu Province Key Laboratory of Modern Pathogen Biology, China
Pattern recognition receptors (PRRs) mediated innate and adaptive activation during helminth infection; Metabolic abnormalities caused by infection immunity; Impact of pathogen-derived molecules on immunometabolism.
Hong You, Ph.D.
Molecular Parasitology Laboratory, The QIMR Berghofer Medical Institute, Australia
Isolation and characterization of specific genes as veterinary vaccine candidates against schistosomiasis; receptor tyrosine kinases of parasites.
Leow Chiuan Yee, Ph.D.
School of Pharmaceutical Sciences, Universiti Sains Malaysia, Malaysia
Website: https://informm.usm.my/ yee.leow
Biologics discovery, antibody engineering and therapeutics (vaccine) development, and diagnostics assay for communicable diseases.
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